Tanita J
Department of Otolaryngology, Hirosaki University School of Medicine.
Nihon Jibiinkoka Gakkai Kaiho. 1992 Sep;95(9):1421-9. doi: 10.3950/jibiinkoka.95.1421.
It is well known that the "placental form of glutathione S-transferase" (GST-pi) is present in high concentrations in most human carcinomas. However, its expression in head and neck carcinomas have not yet been reported. The author investigated the expression of GST-pi in the tissue of pharyngeal and laryngeal carcinomas by the immunohistochemical procedure, and the following results were obtained: 1) GST-pi was positive in 80% of laryngeal carcinomas (35 cases) and 52.8% of pharyngeal carcinomas (36 cases). As a rule, well differentiated squamous cell carcinomas showed stronger expression of GST-pi than poorly differentiated squamous cell carcinomas. 2) Although normal epithelia of the pharynx and larynx showed negative GST-pi, it should be noticed that 54.6% of precancerous epithelia (11 cases) showed positive GST-pi. 3) Most patients treated with radiotherapy showed the diminution of GST-pi expression after the irradiation. However, co-relation between the strength of initial GST-pi expression and the effectiveness of radiotherapy was not observed (p < 0.01).
众所周知，“谷胱甘肽S-转移酶胎盘型”（GST-π）在大多数人类癌组织中浓度很高。然而，其在头颈部癌中的表达尚未见报道。作者采用免疫组织化学方法研究了GST-π在咽喉癌组织中的表达，结果如下：1）80%的喉癌（35例）和52.8%的咽癌（36例）中GST-π呈阳性。通常，高分化鳞状细胞癌比低分化鳞状细胞癌GST-π表达更强。2）虽然咽喉正常上皮GST-π呈阴性，但应注意到54.6%的癌前上皮（11例）GST-π呈阳性。3）大多数接受放疗的患者放疗后GST-π表达降低。然而，未观察到初始GST-π表达强度与放疗效果之间的相关性（p<0.01）。
