Eimoto H, Tsutsumi M, Nakajima A, Yamamoto K, Takashima Y, Maruyama H, Konishi Y
Department of Oncological Pathology, Nara Medical College, Japan.
Carcinogenesis. 1988 Dec;9(12):2325-7. doi: 10.1093/carcin/9.12.2325.
Expression of glutathione S-transferase placental form (GST-pi) in human lung carcinoma tissue taken at autopsy or biopsy was investigated immunohistochemically. All of 34 cases of squamous cell carcinomas, including poorly, moderately and well-differentiated examples were shown to stain positively for GST-pi. Poorly differentiated adenocarcinomas were, however, negatively stained (0/5 cases), while moderately and well differentiated adenocarcinomas were found to stain with GST-pi at rates of 69% (9/13 cases) and 71% (5/7 cases), respectively. Six cases of small cell carcinomas examined were all negative. The results indicate that GST-pi may be a useful marker for non-small cell type lung cancer, especially squamous cell carcinoma which is in agreement with findings for rat lung neoplastic lesions reported previously.
采用免疫组织化学方法研究了尸检或活检获取的人肺癌组织中谷胱甘肽S-转移酶胎盘型（GST-pi）的表达情况。34例鳞状细胞癌，包括低分化、中分化和高分化病例，均显示GST-pi染色阳性。然而，低分化腺癌呈阴性染色（0/5例），而中分化和高分化腺癌的GST-pi染色率分别为69%（9/13例）和71%（5/7例）。所检查的6例小细胞癌均为阴性。结果表明，GST-pi可能是非小细胞型肺癌尤其是鳞状细胞癌的有用标志物，这与先前报道的大鼠肺肿瘤病变的研究结果一致。
