Shibayama Y, Hashimoto K, Nakata K
Department of Pathology, Osaka Medical College, Japan.
J Pathol. 1992 Aug;167(4):421-4. doi: 10.1002/path.1711670412.
We often see perilobular necrosis of the pancreas in patients with liver disease at autopsy. This study was undertaken to determine the frequency and the mechanism of development of pancreatic perilobular necrosis in patients with liver disease. Pancreatic perilobular necrosis was seen in 21 per cent of 261 autopsied patients: in 41 per cent of 73 autopsied patients with liver disease and in 13 per cent of 188 autopsied patients without liver disease. Moreover, splanchnic congestion was present in 90 per cent of 30 pancreatic perilobular necrosis patients with liver disease. These data indicate that patients with liver disease develop perilobular necrosis of the pancreas more often than patients without liver disease, and that the high frequency may be a sequela of splanchnic congestion; that is, congestion of the pancreas and endotoxaemia due to congestion of the gut.
我们常在肝病患者尸检时见到胰腺小叶周围坏死。本研究旨在确定肝病患者胰腺小叶周围坏死的发生频率及机制。在261例尸检患者中，21%出现胰腺小叶周围坏死：73例肝病尸检患者中41%出现，188例无肝病尸检患者中13%出现。此外，30例有肝病的胰腺小叶周围坏死患者中，90%存在内脏充血。这些数据表明，肝病患者比无肝病患者更常发生胰腺小叶周围坏死，且高发生率可能是内脏充血的后遗症，即胰腺充血及肠道充血导致的内毒素血症。
