Vyas S P, Jain C P
Department of Pharmaceutical Sciences, Dr H. S. Gour Vishwavidyalaya, Sagar (M.P.), India.
J Microencapsul. 1992 Oct-Dec;9(4):457-64. doi: 10.3109/02652049209040484.
A polymer-grafted mucoadhesive system bearing isosorbide dinitrate was prepared for buccal administration. Polymer grafting of starch microspheres modified drug release and surface characteristics of microspheres. Bioadhesion and factors affecting bioadhesion were studied. Process variables that could affect microsphere size, and as a result the release of the drug, were also studied. It was observed that compression of grafted starch microspheres modified drug release and extended drug action via slow release following buccal application. Prepared system(s) were characterized for drug release and in vivo performance and compared with conventional oral treatment. The systems were noted to be promising.
制备了一种负载硝酸异山梨酯的聚合物接枝黏膜黏附系统用于颊部给药。淀粉微球的聚合物接枝改变了药物释放以及微球的表面特性。研究了生物黏附性及影响生物黏附的因素。还研究了可能影响微球大小进而影响药物释放的工艺变量。观察到接枝淀粉微球的压制改变了药物释放，并通过颊部给药后的缓释延长了药物作用。对制备的系统进行了药物释放和体内性能表征，并与传统口服治疗进行了比较。这些系统被认为很有前景。
