Salamat-Miller Nazila, Chittchang Montakarn, Johnston Thomas P
Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 5005 Rockhill Road, Room 211A, Kansas City, MO 64110-2499, USA.
Adv Drug Deliv Rev. 2005 Nov 3;57(11):1666-91. doi: 10.1016/j.addr.2005.07.003. Epub 2005 Sep 23.
Buccal delivery of the desired drug using mucoadhesive polymers has been the subject of interest since the early 1980s. Advantages associated with buccal drug delivery have rendered this route of administration useful for a variety of drugs. This review highlights the use of mucoadhesive polymers in buccal drug delivery. Starting with a review of the oral mucosa, mechanism of drug permeation, and characteristics of the desired polymers, this article then proceeds to cover the theories behind the adhesion of bioadhesive polymers to the mucosal epithelium. Additionally, we focus on the new generation of mucoadhesive polymers such as thiolated polymers, followed by the recent mucoadhesive formulations for buccal drug delivery.
自20世纪80年代初以来，使用粘膜粘附聚合物进行所需药物的颊部给药一直是人们关注的课题。与颊部给药相关的优势使这种给药途径对多种药物都很有用。本综述重点介绍了粘膜粘附聚合物在颊部给药中的应用。本文首先回顾了口腔粘膜、药物渗透机制和所需聚合物的特性，然后阐述了生物粘附聚合物与粘膜上皮粘附背后的理论。此外，我们重点关注新一代的粘膜粘附聚合物，如硫醇化聚合物，接着介绍了最近用于颊部给药的粘膜粘附制剂。
