采用溶剂蒸发技术对硫酸特布他林进行微囊化。
Microencapsulation of terbutaline sulphate by the solvent evaporation technique.
作者信息
Manekar N C, Puranik P K, Joshi S B
机构信息
Department of Pharmaceutical Sciences, Nagpur University, India.
出版信息
J Microencapsul. 1992 Oct-Dec;9(4):481-7. doi: 10.3109/02652049209040487.
Terbutaline sulphate microcapsules were prepared by coacervation-phase separation (solvent evaporation) technique using ethyl cellulose as a coating material. Acetone, ethyl alcohol and isopropyl alcohol were employed as solvents for coating material. Microcapsules were evaluated for their drug content, particle size distribution (microscopic method), flow properties, bulk density, in vitro dissolution, drug release kinetics and surface characteristics (scanning electron microscopy).
采用凝聚相分离（溶剂蒸发）技术，以乙基纤维素为包衣材料制备了硫酸特布他林微胶囊。丙酮、乙醇和异丙醇用作包衣材料的溶剂。对微胶囊进行了药物含量、粒度分布（显微镜法）、流动性、堆密度、体外溶出度、药物释放动力学和表面特性（扫描电子显微镜）等方面的评估。
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