Fabre L F, Gainey A, Kemple S
J Int Med Res. 1977;5(1):26-32. doi: 10.1177/030006057700500104.
Twenty out-patients suffering from anxiety and tension after withdrawal from alcohol were treated for 28 days with alprazolam. Three patients dropped out for intercurrent events, and 2 dropped out for recurrent drinking. Of the 15 patients completing the study, analysis of variance showed significant improvement in all Physician's Ratings as well as all patient self-ratings. At the 28th day, 93% of the patients rated moderate to marked improvement on the Physician's Global Impression and Therapeutic Effect, and 93% self rated at least a little better. Side-effects were generally mild and inconsequential. No adverse effects attributable to alprazolam were noted on laboratory evaluations, EKG's or ophthalmologic examinations.
20名戒酒后患焦虑和紧张症的门诊患者接受了阿普唑仑治疗，为期28天。3名患者因并发事件退出，2名患者因再次饮酒退出。在完成研究的15名患者中，方差分析显示所有医生评分以及所有患者自评均有显著改善。在第28天，93%的患者在医生整体印象和治疗效果方面评为中度至显著改善，93%的患者自评至少稍有好转。副作用一般较轻且无关紧要。实验室评估、心电图或眼科检查未发现归因于阿普唑仑的不良反应。
