Servít Z, Strejcková A
Physiol Bohemoslov. 1977(2):143-8.
The effect of acetyldexphenmetrazine (ADP) and dexphenmetrazine (DP) on normal and epileptic electrographic activities in the cortical and thalamic structures of the turtle brain were studied in curarized and artificially ventilated animals. Both drugs almost exclusively influenced cortical activities. The effect of low doses of ADP and DP was similar--they desynchronized cortical activity and suppressed the activity of a cortical penicillin focus. They also elevated the cortical response to optic stimuli. Higher doses of ADP continued to suppress both normal and epileptic cortical activities. Higher doses of DP had a two phase effect with enhancement of epileptic activity in the first phase. Continuous trains of theta activity appeared after low doses of ADP and very often after both low and high doses of DP. The findings are discussed in terms of comparative physiology of the brain.
在箭毒化并进行人工通气的动物身上，研究了乙酰右苯丙胺（ADP）和右苯丙胺（DP）对龟脑皮质和丘脑结构中正常和癫痫性电图活动的影响。两种药物几乎只影响皮质活动。低剂量的ADP和DP效果相似——它们使皮质活动去同步化，并抑制皮质青霉素病灶的活动。它们还增强了皮质对视刺激的反应。高剂量的ADP继续抑制正常和癫痫性皮质活动。高剂量的DP有两阶段效应，第一阶段癫痫活动增强。低剂量的ADP后以及低剂量和高剂量的DP后常常会出现连续的θ活动序列。根据大脑的比较生理学对这些发现进行了讨论。
