Soothill J S
Department of Infection, Medical School, Edgbaston, Birmingham.
J Med Microbiol. 1992 Oct;37(4):258-61. doi: 10.1099/00222615-37-4-258.
Bacteriophages for Acinetobacter baumanii, Pseudomonas aeruginosa and Staphylococcus aureus were tested in experimental infections of mice to investigate their potential for the treatment of infections of man. As few as 10(2) particles of an acinetobacter phage protected mice against 5 LD50 (1 x 10(8)) of a virulent strain of A. baumanii, and phage was demonstrated to have multiplied in the mice. A pseudomonas phage protected mice against 5 LD50 of a virulent strain of P. aeruginosa, with a PD50 of 1.2 x 10(7) particles. A staphylococcal phage failed to protect mice infected with a strain of S. aureus. These studies support the view that bacteriophages could be useful in the treatment of human infections caused by antibiotic-resistant strains of bacteria.
对用于鲍曼不动杆菌、铜绿假单胞菌和金黄色葡萄球菌的噬菌体进行了小鼠实验性感染测试，以研究它们治疗人类感染的潜力。低至10²个鲍曼不动杆菌噬菌体颗粒就能保护小鼠抵御5个半数致死量（1×10⁸）的强毒鲍曼不动杆菌菌株，并且证明噬菌体在小鼠体内繁殖。一种铜绿假单胞菌噬菌体保护小鼠抵御5个半数致死量的强毒铜绿假单胞菌菌株，半数有效剂量为1.2×10⁷个颗粒。一种葡萄球菌噬菌体未能保护感染金黄色葡萄球菌菌株的小鼠。这些研究支持了噬菌体可用于治疗由抗生素耐药性细菌菌株引起的人类感染这一观点。
