Jiang Ping, Luo Xiaoqin, Zhao Jing, Sun Jingwei, Su Zhanhai, Cheng Peng
Department of Basic Medical Sciences, Qinghai University Medical College, Xining, China.
Department of Clinical Laboratory, Qinghai Provincial People's Hospital, Xining, China.
Front Microbiol. 2025 Jun 24;16:1606351. doi: 10.3389/fmicb.2025.1606351. eCollection 2025.
is a common hospital pathogen that poses a serious clinical challenge due to its rapidly increasing resistance to antibiotics. Phage therapy has been successfully used to treat antibiotic resistant infections. The aim of this study was to comprehensively assess the current status and trend of research on the application of phages in infections through bibliometric analysis.
Studies on phages and infections were searched in the Web of Science Core Collection database and relevant articles were selected for inclusion in the study based on the inclusion criteria. Bibliometric and visual analysis of the included publications were performed using VOSviewer and CiteSpace software.
A total of 264 studies were included. There is an increasing trend in the number of publications per year from 2010 to 2024. China was the leading country with 35.98% of the total publications. Tzu Chi University and Lin, Nien-Tsung were the most influential institution and author, respectively. The journal with the highest H-index was Frontiers in Microbiology, and Viruses-Basel was the most prolific journal. Antimicrobial Agents and Chemotherapy was the most cited journal. Phages endolysin and phage therapy were found to be the widely researched aspects, biofilm, phage resistance and synergistic effect are recent research hotspots.
In the last decade or so, this is the first bibliometric study that systematically describes the research hotspots and development trends on phages in infections. Research hotspots should be given more attention.
是一种常见的医院病原体，由于其对抗生素的耐药性迅速增加，给临床带来了严峻挑战。噬菌体疗法已成功用于治疗抗生素耐药性感染。本研究的目的是通过文献计量分析全面评估噬菌体在感染中的应用研究现状和趋势。
在科学网核心合集数据库中检索关于噬菌体和感染的研究，并根据纳入标准选择相关文章纳入本研究。使用VOSviewer和CiteSpace软件对纳入的出版物进行文献计量和可视化分析。
共纳入264项研究。2010年至2024年每年的出版物数量呈上升趋势。中国是领先国家，占总出版物的35.98%。慈济大学和林念宗分别是最具影响力的机构和作者。H指数最高的期刊是《微生物前沿》，《病毒-巴塞尔》是发文量最多的期刊。《抗菌药物与化疗》是被引用最多的期刊。发现噬菌体溶菌酶和噬菌体疗法是研究广泛的方面，生物膜、噬菌体抗性和协同效应是最近的研究热点。
在过去十年左右的时间里，这是第一项系统描述噬菌体在感染中的研究热点和发展趋势的文献计量研究。应更多关注研究热点。
