Kitabatake M, Yoshida K, Kasama K, Murase S, Yuan P F, Manjurul H, Yamauchi T
Department of Public Health, School of Medicine, Mie University, Tsu, Japan.
J Toxicol Environ Health. 1992 Oct;37(2):265-75. doi: 10.1080/15287399209531669.
An automated system was developed for evaluating changes in respiratory symptoms in guinea pigs over a long period with a personal computer. The data on breathing curves obtained with a body plethysmograph were analyzed to determine respiratory rate, expiration/inspiration ratio, ventilation ratio, and other parameters. With this system, respiratory changes in guinea pigs, such as increase or decrease of respiratory rate, expiration/inspiration ratio, and ventilation ratio, and death of animals could be easily observed. Investigation of delayed respiratory response to Candida albicans in sensitized guinea pigs and of the effects of SO2 or NO2 exposures on its response was carried out using this system. Respiratory changes in delayed respiratory response were mostly increased respiration rate and succeeding expiratory prolongation being noted just before death. In the influences of SO2 or NO2 exposure on delayed respiratory response, increase of respiratory rate in NO2 and expiratory and inspiratory prolongation in SO2 were found. This system should prove useful for evaluating changes in respiratory symptoms due to toxic agents, medicines, and air pollutants in small animals.
开发了一种自动化系统，用于通过个人计算机长期评估豚鼠呼吸症状的变化。分析用体容积描记器获得的呼吸曲线数据，以确定呼吸频率、呼气/吸气比、通气比和其他参数。使用该系统，可以轻松观察到豚鼠的呼吸变化，如呼吸频率、呼气/吸气比和通气比的增加或减少以及动物的死亡。利用该系统研究了致敏豚鼠对白色念珠菌的延迟呼吸反应以及二氧化硫或二氧化氮暴露对其反应的影响。延迟呼吸反应中的呼吸变化大多是呼吸频率增加，并且在死亡前注意到随后的呼气延长。在二氧化硫或二氧化氮暴露对延迟呼吸反应的影响方面，发现二氧化氮会使呼吸频率增加，二氧化硫会使呼气和吸气延长。该系统对于评估小动物中有毒物质、药物和空气污染物引起的呼吸症状变化应是有用的。
