Müller E, Bergmann K C, Lachmann B, Vogel J
Z Erkr Atmungsorgane. 1976 Mar;144(3):246-53.
Allergic asthma-like attacks were induced in guinea pigs by intraperitoneal injections of Ovalbumin and following inhalation of Ovalbumin aerosol. The animals were narcotized, tracheotomized and a small catheter was placed in mid-oesophagus. The quantities: oesophageal pressure, respiratory flow and tidal volume were measured and recorded on magnetic tape during spontaneous breathing. A technique was applied for automated computation of the parameters of respiratory mechanics using a digital computer. The parameters compliance, resistance, work of breathing and power of breathing showed typical pathological variances and characteristic response-curves in the experimental phases during and after the asthma attacks. These parameters became normal after the injection of Alupent.
通过腹腔注射卵清蛋白并随后吸入卵清蛋白气雾剂，在豚鼠身上诱发类似过敏性哮喘的发作。将动物麻醉、进行气管切开，并在食管中部放置一根小导管。在自主呼吸过程中，测量食管压力、呼吸流量和潮气量，并记录在磁带上。应用一种技术，使用数字计算机自动计算呼吸力学参数。顺应性、阻力、呼吸功和呼吸功率等参数在哮喘发作期间及之后的实验阶段显示出典型的病理变化和特征性反应曲线。注射间羟异丙肾上腺素后，这些参数恢复正常。
