Sun Y C, Geldof A A, Newling D W, Rao B R
Department of Endocrinology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.
J Urol. 1992 Oct;148(4):1270-3. doi: 10.1016/s0022-5347(17)36890-8.
Prostate tumor cell metastasis to the axial skeleton was induced in male Copenhagen rats using the intravenous injection of syngeneic metastatic R3327-MATLyLu tumor cells and concomitant caval vein clamping. The proliferation of tumor cells in the lumbar region was monitored by the progression, within 19 days post tumor cell injection, of hindleg paralysis which appeared in these animals. Histology confirmed the presence of tumor cells within the lumbar spine in 100% of cases displaying hindleg paralysis. Treatment with either of the bisphosphonate drugs, Cl2MDP or APD, suppressed and delayed the development of hind leg paralysis. Bisphosphonate treatment may be expected to delay the onset of axial skeletal metastasis effects in prostate cancer patients.
通过静脉注射同基因转移性R3327-MATLyLu肿瘤细胞并同时钳夹腔静脉，在雄性哥本哈根大鼠中诱导前列腺肿瘤细胞转移至中轴骨骼。在肿瘤细胞注射后19天内，通过这些动物出现的后肢麻痹进展来监测腰区肿瘤细胞的增殖。组织学证实，在100%出现后肢麻痹的病例中，腰椎内存在肿瘤细胞。使用双膦酸盐药物Cl2MDP或APD进行治疗可抑制并延缓后肢麻痹的发展。双膦酸盐治疗有望延缓前列腺癌患者中轴骨转移效应的发生。
