D-丙氨酸对D-环丝氨酸抑制分枝杆菌生长的拮抗作用
ANTAGONISM OF D-CYCLOSERINE INHIBITION OF MYCOBACTERIAL GROWTH BY D-ALANINE.
作者信息
ZYGMUNT W A
出版信息
J Bacteriol. 1963 Jun;85(6):1217-20. doi: 10.1128/jb.85.6.1217-1220.1963.
Abstract
Zygmunt, Walter A. (Mead Johnson & Co., Evansville, Ind.). Antagonism of d-cycloserine inhibition of mycobacterial growth by d-alanine. J. Bacteriol. 85:1217-1220. 1963.-Reversal of the antimycobacterial activity of d-4-amino-3-isoxazolidinone (d-cycloserine) by alanine in two species of mycobacteria actively growing on chemically defined media was compared. In both instances, d-alanine was the most effective reversal agent. The specificity with which the d isomer reversed the antimycobacterial activity of d-cycloserine was more pronounced than that observed with other species of bacteria. Mycobactin, a growth factor for certain mycobacteria, showed no reversal activity.
摘要
齐格蒙特，沃尔特·A.（美赞臣公司，印第安纳州埃文斯维尔）。D-丙氨酸对D-环丝氨酸抑制分枝杆菌生长的拮抗作用。《细菌学杂志》85:1217 - 1220。1963年。——比较了在化学成分确定的培养基上活跃生长的两种分枝杆菌中，丙氨酸对D-4-氨基-3-异恶唑烷酮（D-环丝氨酸）抗分枝杆菌活性的逆转作用。在这两种情况下，D-丙氨酸都是最有效的逆转剂。D-异构体逆转D-环丝氨酸抗分枝杆菌活性的特异性比在其他细菌中观察到的更为明显。分枝杆菌素，一种某些分枝杆菌的生长因子，没有逆转活性。
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