Sakai M
Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1992 Jul;30(7):1265-73.
Resting energy expenditure (REE) and respiratory heat loss (RHL) were measured in 17 patients with chronic obstructive pulmonary disease (COPD), 7 patients with pulmonary fibrosis (PF), and 8 normal healthy subjects, three hours after a light breakfast. Correlations between these values, and also predicted basal metabolic rate (PreBMR) and normalized lung functions were assessed. REE, REE/Pre BMR, RHL and RHL/REE in all patients increased significantly compared with those of control subjects. When all the studied subjects were combined, significant negative relationships were found between REE, REE/PreBMR, RHL and RHL/REE and percent predicted values of forced expiratory volume in one second (FEV1.0), between RHL and RHL/REE and percent predicted values of vital capacity (VC), and between REE/PreBMR, RHL and RHL/REE and percent predicted values of carbon monoxide diffusing capacity (DLCO). These results indicate that resting energy expenditure and respiratory heat loss increase in patients with COPD and PF in association with even slight to moderate deterioration of lung function. Therefore, elevated resting energy expenditure and respiratory heat loss need to be taken into account in determining caloric and water requirements of these patients.
在17例慢性阻塞性肺疾病（COPD）患者、7例肺纤维化（PF）患者和8名正常健康受试者早餐后3小时测量静息能量消耗（REE）和呼吸热损失（RHL）。评估了这些值之间的相关性，以及预测基础代谢率（PreBMR）和标准化肺功能之间的相关性。与对照组相比，所有患者的REE、REE/PreBMR、RHL和RHL/REE均显著增加。当所有研究对象合并时，发现REE、REE/PreBMR、RHL和RHL/REE与一秒用力呼气量（FEV1.0）的预测值百分比之间、RHL和RHL/REE与肺活量（VC）的预测值百分比之间、以及REE/PreBMR、RHL和RHL/REE与一氧化碳弥散量（DLCO）的预测值百分比之间存在显著负相关。这些结果表明，COPD和PF患者的静息能量消耗和呼吸热损失增加，与肺功能即使轻微至中度恶化有关。因此，在确定这些患者的热量和水分需求时，需要考虑静息能量消耗和呼吸热损失的升高。
