Fitting J W, Frascarolo P, Jéquier E, Leuenberger P
Département de Médecine Interne, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Eur Respir J. 1989 Oct;2(9):840-5.
The resting energy expenditure (REE) was measured by indirect calorimetry in 10 patients with chronic obstructive pulmonary disease (COPD) in stable clinical state and in 10 normal subjects. In order to avoid artefactually increased values, REE was obtained from prolonged measurements in steady state using a ventilated hood, without facial apparatus. The REE of COPD patients was significantly increased to 117% of predicted basal metabolic rate and to 125% of the control group values. Rib cage and abdominal movements were measured in COPD patients by inductance plethysmography and expressed with three indices: rib cage contribution to tidal volume (RC/VT), variability in compartmental contribution to tidal volume (SD RC/VT), and maximal compartmental amplitude/tidal volume ratio (MCA/VT). No correlation was found between REE and any of the indices of rib cage and abdominal motion. We conclude that the REE is increased in patients with COPD in stable clinical state, but is not related to the degree of abnormal rib cage-abdominal motion.
采用间接测热法对10例临床状态稳定的慢性阻塞性肺疾病（COPD）患者及10名正常受试者的静息能量消耗（REE）进行了测量。为避免人为导致数值升高，在稳态下使用无面部装置的通气罩进行长时间测量以获取REE。COPD患者的REE显著升高，达到预测基础代谢率的117%，以及对照组数值的125%。通过电感式体积描记法测量COPD患者的胸廓和腹部运动，并以三个指标表示：胸廓对潮气量的贡献（RC/VT）、各腔室对潮气量贡献的变异性（SD RC/VT）以及最大腔室振幅/潮气量比值（MCA/VT）。未发现REE与胸廓和腹部运动的任何指标之间存在相关性。我们得出结论，临床状态稳定的COPD患者的REE升高，但与胸廓 - 腹部异常运动的程度无关。
