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[情绪应激对实验动物某些中枢神经区域及心脏中儿茶酚胺和多巴水平的影响]

[Effect of emotional stress on catecholamine and dopa levels in some central nervous regions and in the heart of experimental animals].

作者信息

Kiseleva Z M

出版信息

Kardiologiia. 1992 May;32(5):81-4.

PMID:1405274
Abstract

The paper presents the results of examining the levels of dopamine, norepinephrine, epinephrine and precursors of their DOPA biosynthesis in the hypothalamus, hypophysis, medulla oblongata, adrenals and heart in miniature pigs exposed to acute stress. The acute emotional stress was shown to be characterized by a significant increase in the activity of the brain hypothalamic region, adrenals, peripheral portion of the sympathoadrenal system, as evidenced by higher norepinephrine release and hence lower neurotransmitter levels in the above structures. This resulted in abnormal physiological norepinephrine/epinephrine ratios in the central nervous system and heart, predisposing to myocardial metabolic and electric instability.

摘要

本文呈现了对遭受急性应激的小型猪的下丘脑、垂体、延髓、肾上腺和心脏中多巴胺、去甲肾上腺素、肾上腺素及其多巴生物合成前体水平进行检测的结果。急性情绪应激的特征表现为脑下丘脑区域、肾上腺、交感肾上腺系统外周部分的活性显著增加,这由去甲肾上腺素释放增加以及上述结构中神经递质水平降低所证实。这导致中枢神经系统和心脏中生理去甲肾上腺素/肾上腺素比值异常,易引发心肌代谢和电不稳定。

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