Annino D J, MacArthur C J, Friedman E M
Children's Hospital, Boston, MA.
Laryngoscope. 1992 Nov;102(11):1260-2. doi: 10.1288/00005537-199211000-00011.
Vincristine-sulfate-related vocal cord paralysis has been reported infrequently in the literature. The neurotoxicity of the vinca alkaloids is well-known; however, the potential for cranial nerve involvement is not widely recognized. Given the complexity of the typical patient receiving such a chemotherapeutic agent, the potential for misdiagnosis is high. Many patients have primary tumors or metastatic lesions in sites that could cause the clinician to overlook this reversible cause of neurologic dysfunction. This study describes the first three reported pediatric cases of vincristine-induced vocal cord paralysis. Two patients developed increasing stridor secondary to bilateral vocal cord paralysis; the third developed a unilateral vocal cord paralysis. All resolved spontaneously upon withdrawal of the vincristine. Vinca-alkaloid-induced vocal cord paralysis is a potentially dangerous but reversible lesion. Otolaryngologists should be aware of the association between these agents and cranial nerve neuropathies.
文献中关于硫酸长春新碱相关声带麻痹的报道较少。长春花生物碱的神经毒性是众所周知的；然而，其累及颅神经的可能性尚未得到广泛认识。鉴于接受此类化疗药物的典型患者情况复杂，误诊的可能性很高。许多患者的原发肿瘤或转移病灶所在部位可能导致临床医生忽略这种可逆性神经功能障碍的病因。本研究描述了首例报道的3例长春新碱诱导的小儿声带麻痹病例。2例患者因双侧声带麻痹出现喘鸣加重；第3例出现单侧声带麻痹。停用长春新碱后，所有病例均自发缓解。长春花生物碱诱导的声带麻痹是一种潜在危险但可逆的病变。耳鼻喉科医生应了解这些药物与颅神经病变之间的关联。
