Tobias J D, Bozeman P M
St. Jude Children's Research Hospital, Department of Anesthesia, Memphis, Tennessee.
Intensive Care Med. 1991;17(5):304-5. doi: 10.1007/BF01713944.
Stridor developed in 2 children during vincristine therapy for malignancies. Indirect laryngoscopy revealed left vocal cord paralyses in both patients. One child had generalized neurotoxicity from vincristine including hypotonia, decreased gastrointestinal motility, and painful paresthesias while laryngeal nerve paralysis was the only neurotoxic manifestation in the other patient. Stridor resolved in both patients after discontinuing or decreasing the dose of vincristine. Visualization of the airway not only confirms the diagnosis, but also rules out treatable causes of stridor in the febrile, immunocompromised patient.
在2名患有恶性肿瘤的儿童接受长春新碱治疗期间出现了喘鸣。间接喉镜检查显示两名患者均有左侧声带麻痹。一名儿童出现了长春新碱引起的全身性神经毒性，包括肌张力减退、胃肠蠕动减慢和疼痛性感觉异常，而另一名患者的喉神经麻痹是唯一的神经毒性表现。在停用或减少长春新碱剂量后，两名患者的喘鸣均消失。气道可视化不仅能确诊，还能排除发热、免疫功能低下患者喘鸣的可治疗原因。
