Cartel J L, Boutin J P, Spiegel A, Glaziou P, Plichart R, Cardines R, Grosset J H
Institut Territorial de Recherches Medicales Louis Malarde, Tahiti, Polyneise Francaise.
Lepr Rev. 1992 Sep;63(3):211-22. doi: 10.5935/0305-7518.19920026.
The analysis of computerized data (OMSLEP system) on patients from French Polynesia followed since 1940 has shown a decrease in the mean annual detection rates for leprosy, all forms combined, from 24.73 per 100,000 inhabitants in 1946 to 8.1 per 100,000 in 1987 (y = -0.49 x + 45.83; p < 0.05). In fact, the decrease was significant (y = -1.18 x + 83.54; p < 0.05) during the first half of the study period (1946-66), but not during the second half (1967-87). Similarly, a significant decrease in all of the specific mean annual detection rates (according to the form of leprosy and to the sex and age of patients), in the proportion of multibacillary patients among the total of newly detected cases, and in the proportion of all patients with disabilities at the onset of leprosy was observed only during the first half of the study period (1946-66). Nevertheless, when comparing age-specific cumulative detection rates, calculated by 10-year age groups over the period 1946-66, to those of the period 1967-87, an ageing of the leprosy population was noted. Finally, the decrease of mean annual detection rates was greater in the smaller populations of remote islands than in the population of Tahiti, the main island, where 70% of the total population were living during the study period. This decline was shown to correspond to an effective improvement of the leprosy situation which could be attributed, among other factors (such as economic development and systematic BCG vaccination), to the implementation of a control programme for leprosy in 1950. The introduction in 1982 of multidrug therapy for all patients suffering active leprosy has raised the hope of a subsequent decline of leprosy in French Polynesia in the near future.
对自1940年起跟踪的法属波利尼西亚患者的计算机化数据（OMSLEP系统）分析显示，麻风病所有类型合并计算的年平均检出率有所下降，从1946年的每10万居民24.73例降至1987年的每10万居民8.1例（y = -0.49x + 45.83；p < 0.05）。事实上，在研究期的前半段（1946 - 1966年）下降显著（y = -1.18x + 83.54；p < 0.05），但后半段（1967 - 1987年）并非如此。同样，仅在研究期的前半段（1946 - 1966年）观察到所有特定年平均检出率（根据麻风病类型以及患者性别和年龄）、新发病例总数中多菌型患者的比例以及麻风病发病时所有残疾患者的比例均显著下降。然而，在比较1946 - 1966年期间按10岁年龄组计算的特定年龄累积检出率与1967 - 1987年期间的累积检出率时，发现麻风病患者群体出现了老龄化。最后，偏远小岛屿人群中年平均检出率的下降幅度大于主要岛屿塔希提岛人群，在研究期间，70%的总人口居住在塔希提岛。这种下降表明麻风病状况得到了有效改善，这除了其他因素（如经济发展和系统性卡介苗接种）外，可归因于1950年实施的麻风病控制计划。1982年对所有活动性麻风病患者引入多药疗法带来了法属波利尼西亚麻风病在不久的将来随后下降 的希望。
