Cartel J L, Chanteau S, Boutin J P, Plichart R, Richez P, Roux J F, Grosset J H
Institut Louis Malarde, Papeete, Tahiti, French Polynesia.
Int J Lepr Other Mycobact Dis. 1990 Sep;58(3):512-7.
Anti-phenolic glycolipid-I (PGL-I) IgM levels were determined in 96% of the general population of the Southern Marquesas and Maupiti, remote islands of French Polynesia, where the average annual detection rates of leprosy during the past 30 years have been 57.1 and 4.4 per 100,000, respectively. The seropositivity in these two areas was 4.3% and 4.2%, respectively. No significant difference (p greater than 0.05) was found between either these two figures or between the percentages of persons with high (greater than or equal to 0.500 OD) anti-PGL-I IgM levels (9.2% and 5.3%). In the two islands, the age distributions of anti-PGL-I IgM were very similar; the percentage of positive responders was higher in females than in males and higher in adolescents than in adults. These results suggest that the usefulness of the determination of anti-PGL-I IgM levels by ELISA, using the synthetic trisaccharide as antigen, for detecting Mycobacterium leprae infection in leprosy control programs is extremely doubtful.
在法属波利尼西亚的偏远岛屿马克萨斯群岛南部和莫皮蒂岛，96%的普通人群接受了抗酚糖脂-I（PGL-I）IgM水平检测，过去30年中，这两个岛屿麻风病的年均检出率分别为每10万人57.1例和4.4例。这两个地区的血清阳性率分别为4.3%和4.2%。这两个数字之间以及抗PGL-I IgM水平较高（大于或等于0.500 OD）的人群百分比（9.2%和5.3%）之间均未发现显著差异（p大于0.05）。在这两个岛屿上，抗PGL-I IgM的年龄分布非常相似；女性阳性反应者的百分比高于男性，青少年高于成年人。这些结果表明，在麻风病控制项目中，使用合成三糖作为抗原通过ELISA法检测抗PGL-I IgM水平来检测麻风杆菌感染的实用性极其可疑。
