Ryan W G
Annu Rev Med. 1977;28:143-52. doi: 10.1146/annurev.me.28.020177.001043.
Paget's disease affects approximately 3% of the population over age forty. It may be genetically transmitted (autosomal-dominant), but recent evidence suggests a viral etiology. Effective agents for control of the disorder have been developed over the past decade, but all have significant drawbacks. Calcitonin tends to lose its effectiveness in significant numbers of patients over a few months, mithramycin has significant toxicity, and diphosphonates tend to cause osteomalacia.
佩吉特氏病影响约3%的40岁以上人群。它可能是遗传传递的（常染色体显性遗传），但最近的证据表明其病因是病毒。在过去十年中已研发出控制该疾病的有效药物，但所有药物都有显著缺点。降钙素在几个月内会使大量患者失去疗效，光辉霉素有显著毒性，双膦酸盐则易导致骨软化症。
