使用胰高血糖素、降钙素和光辉霉素治疗变形性骨炎

Control of osteitis deformans using glucagon, calcitonin, and mithramycin.

作者信息

Condon J R, Surtees J, Robinson V

出版信息

Postgrad Med J. 1981 Feb;57(664):84-8. doi: 10.1136/pgmj.57.664.84.

DOI:10.1136/pgmj.57.664.84

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2424817/

Abstract

Glucagon, porcine calcitonin, and mithramycin were given to patients with Paget's disease of bone. There was rapid complete relief of bone pain accompanied by biochemical improvement or normalization in all cases. Calcitonin and glucagon appear to have additive properties in Paget's disease and the use of the 3 drugs in combination may reduce the incidence of side effects and the development of "drug resistance". The cost of treatment might also be reduced if periodic treatment as demonstrated in Case 1 is used.

摘要

向患有骨佩吉特病的患者给予了猪胰高血糖素、猪降钙素和光辉霉素。所有病例均出现骨痛迅速完全缓解，同时伴有生化指标改善或恢复正常。降钙素和胰高血糖素在佩吉特病中似乎具有相加作用，联合使用这三种药物可能会降低副作用的发生率和“耐药性”的产生。如果采用病例1所示的周期性治疗，治疗成本也可能会降低。

相似文献

1

Control of osteitis deformans using glucagon, calcitonin, and mithramycin.使用胰高血糖素、降钙素和光辉霉素治疗变形性骨炎

Postgrad Med J. 1981 Feb;57(664):84-8. doi: 10.1136/pgmj.57.664.84.

2

Combination drug therapy in treatment of Paget's disease of bone: clinical and metabolic response.联合药物治疗骨佩吉特病：临床和代谢反应

J Bone Joint Surg Am. 1977 Dec;59(8):1045-51.

3

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Orthop Clin North Am. 1972 Nov;3(3):775-86.

4

Newer agents in treating Paget's disease of bone.

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5

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Gerontology. 1979;25(3):151-8. doi: 10.1159/000212334.

6

Calcitonin in the treatment of Paget's disease of bone.

Ann Intern Med. 1972 Apr;76(4):665-6. doi: 10.7326/0003-4819-76-4-665_2.

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Paget's disease of bone.骨佩吉特病

Annu Rev Med. 1977;28:143-52. doi: 10.1146/annurev.me.28.020177.001043.

8

[Comparative studies of the behavior of blood calcium and urinary hydroxyproline after infusion of calcitonin and glucagon in patients with Paget's disease].

Boll Soc Ital Biol Sper. 1974 Jan 31;50(1-2):55-61.

9

Paget's disease of the skull and migraine headache.

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10

[Clinical and metabolic effects of mithramycin and glucagon in the treatment of Paget's disease].[光辉霉素与胰高血糖素治疗变形性骨炎的临床及代谢效应]

Union Med Can. 1978 Sep;107(9):849-56.

本文引用的文献

1

Modifications of a specific assay for hydroxyproline in urine.尿中羟脯氨酸特定检测方法的改进。

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Glucagon in the treatment of Paget's disease of bone.胰高血糖素在骨佩吉特病治疗中的应用。

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Effects of calcitonin on patients with Paget's disease, thyrotoxicosis, or hypercalcaemia.降钙素对变形性骨炎、甲状腺毒症或高钙血症患者的影响。

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Diphosphonates and Page's disease of bone.

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Treatment of Paget's disease with (3-amino-1-hydroxypropylidene)-1, 1-bisphosphonate (A.P.D.).用（3-氨基-1-羟基亚丙基）-1,1-二膦酸盐（A.P.D.）治疗佩吉特病。

Lancet. 1979 Apr 14;1(8120):799-803. doi: 10.1016/s0140-6736(79)91318-7.

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