使用胰高血糖素、降钙素和光辉霉素治疗变形性骨炎
Control of osteitis deformans using glucagon, calcitonin, and mithramycin.
作者信息
Condon J R, Surtees J, Robinson V
出版信息
Postgrad Med J. 1981 Feb;57(664):84-8. doi: 10.1136/pgmj.57.664.84.
Glucagon, porcine calcitonin, and mithramycin were given to patients with Paget's disease of bone. There was rapid complete relief of bone pain accompanied by biochemical improvement or normalization in all cases. Calcitonin and glucagon appear to have additive properties in Paget's disease and the use of the 3 drugs in combination may reduce the incidence of side effects and the development of "drug resistance". The cost of treatment might also be reduced if periodic treatment as demonstrated in Case 1 is used.
向患有骨佩吉特病的患者给予了猪胰高血糖素、猪降钙素和光辉霉素。所有病例均出现骨痛迅速完全缓解，同时伴有生化指标改善或恢复正常。降钙素和胰高血糖素在佩吉特病中似乎具有相加作用，联合使用这三种药物可能会降低副作用的发生率和“耐药性”的产生。如果采用病例1所示的周期性治疗，治疗成本也可能会降低。
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