Heckeroth V A, Michel C F
Arch Gynakol. 1977 Mar 31;222(2):103-14. doi: 10.1007/BF00667195.
In 30 rabbits, which had accidentally been divided into five groups of different treatment the effect of the substance Persantin, Actihaemyl and Noleptan was investigated in view of the time of survival of the animals and the behaviour of the acid-base-balance and the blood-gases under conditions of oxygen-delay. There were two control-groups. One collective was treated with Haemaccel, the other with Glucose. In those groups treated with Persantin, Actihaemyl and Noleptan the time of survival of the animals is significantly higher in comparison with the animals of the control-groups. The behaviour of the acid-base-balance and the blood-gases in the collective treated with Persantin points to a reduction of the dimension of the metabolic acidosis. This effect cannot be assumed for Actihaemyl because of this investigation. The effect of Noleptan seems to depend on an improvement of the gas exchange in the lungs of the rabbits. The results of this investigation show that the application of Persantin and Actihaemyl might be an interesting enrichment of the medicamental treatment of the intrauterine acidoses.
在30只兔子中，这些兔子因意外被分成五组接受不同治疗，针对潘生丁、阿克太明和诺利普坦等物质，从动物存活时间以及在氧气延迟条件下酸碱平衡和血气的表现方面进行了研究。设有两个对照组。一组用贺斯治疗，另一组用葡萄糖治疗。与对照组动物相比，接受潘生丁、阿克太明和诺利普坦治疗的组中动物的存活时间显著更长。接受潘生丁治疗的组中酸碱平衡和血气的表现表明代谢性酸中毒程度有所减轻。基于本次研究，阿克太明未呈现此效果。诺利普坦的效果似乎取决于兔子肺部气体交换的改善。本次研究结果表明，应用潘生丁和阿克太明可能为宫内酸中毒的药物治疗提供有趣的补充。
