Truss F, Nabert-Bock G, Zimmermann A
Urologe A. 1976 Jan;15(1):44-7.
The effect of automated continuous irrigation treatment with Actihaemyl on bacterial growth in the infected urinary bladder was tested using an experimental model. The result was that instillation alone of this preparation promoted growth of Escherichia coli, Proteus mirabilis, and Pseudomonas aeruginosa in the infected bladder. With simultaneous application of Framycetinsulfate or Kanamycin the growth of Pr. mirabilis and Ps. aeruginosa was totally suppressed in the "urine", and the growth of E. coli extensively low. At the same time there was a clear reduction in the bacterial count in the coagulum that served as a substitute bladder wall. Thus a urinary tract infection is a contraindication for local treatment with Actihaemyl of a tropically disturbed urinary bladder inasmuch as an effective antibiotic is not added to the instillate. With the latter combination, however, a therapeutic trial is justified in chronic, inflammatory, dystrophic bladders.
使用实验模型测试了Actihaemyl自动持续灌洗治疗对感染膀胱中细菌生长的影响。结果是，单独灌注该制剂会促进感染膀胱中大肠杆菌、奇异变形杆菌和铜绿假单胞菌的生长。同时应用硫酸新霉素或卡那霉素时，“尿液”中奇异变形杆菌和铜绿假单胞菌的生长被完全抑制，大肠杆菌的生长也大幅降低。与此同时，作为替代膀胱壁的凝块中的细菌数量明显减少。因此，由于灌洗液中未添加有效的抗生素，尿路感染是热带性膀胱功能紊乱时局部使用Actihaemyl治疗的禁忌证。然而，对于慢性、炎症性、营养不良性膀胱，采用后一种联合用药进行治疗试验是合理的。
