Matzkies F
Kurparkklinik Bad Neustadt/Saale.
Med Klin (Munich). 1992 Sep 15;87(9):460-2.
Lasting normalisation of uric acid levels after treatment of patients with gout and hyperuricaemia with a combination of 300 mg allopurinol and 60 mg benzbromarone A total of 210 patients (163 men, 47 women) with gout and hyperuricaemia was treated for three months with daily doses of 300 mg allopurinol and 60 mg benzbromarone. During the course of treatment, the uric acid levels decreased to 4.3 +/- 1.3 mg/dl in male, and 4.4 +/- 1.3 mg/dl in female patients. Both of these levels differ significantly from the initial levels (p less than 0.001). Three months after discontinuation of treatment, uric acid levels were 5.7 +/- 1.2 mg/dl in women, and 5.9 +/- 1.4 mg/dl in men, levels that again differed significantly from the initial levels (p less than 0.001); both levels were, however, within the therapeutic range of below 6.4 mg/dl.
使用300毫克别嘌醇和60毫克苯溴马隆联合治疗痛风和高尿酸血症患者后尿酸水平的持久正常化
共有210例痛风和高尿酸血症患者（163例男性，47例女性）接受了为期三个月的每日剂量300毫克别嘌醇和60毫克苯溴马隆治疗。在治疗过程中，男性患者尿酸水平降至4.3±1.3毫克/分升，女性患者降至4.4±1.3毫克/分升。这两个水平均与初始水平有显著差异（p<0.001）。治疗停止三个月后，女性尿酸水平为5.7±1.2毫克/分升，男性为5.9±1.4毫克/分升，这两个水平再次与初始水平有显著差异（p<0.001）；然而，两个水平均在6.4毫克/分升以下的治疗范围内。
