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肥厚心肌等长收缩数学建模的分析方法

Analytical approach to mathematical modelling of the isometric contraction of the hypertrophied myocardium.

作者信息

Vit K

出版信息

Basic Res Cardiol. 1977 Mar-Jun;72(2-3):168-71. doi: 10.1007/BF01906356.

DOI:10.1007/BF01906356
PMID:140659
Abstract

It is attempted on the basis of the Hill two-element model to simulate mathematically the rising phase of the isometric mechanogram in the pressure-hypertrophied rat myocardium (Goldblatt II). The evaluation is based on the experimentally determined force-velocity relation as well as on the characteristic of the series-elastic stiffness. The changes in the isometric mechanogram of the hypertrophied heart muscle observed in the experiment can be mathematically predicted solely by means of the alterations in the force-velocity relationships induced by the hypertrophy, whereby the characteristic of the series-elastic stiffness is considered to be unchanged.

摘要

基于希尔双元件模型，试图对压力超负荷肥大大鼠心肌（戈德布拉特II型）等长机械图的上升阶段进行数学模拟。评估基于实验确定的力-速度关系以及串联弹性刚度的特性。实验中观察到的肥大心肌等长机械图的变化仅通过肥大引起的力-速度关系的改变就能进行数学预测，其中串联弹性刚度的特性被认为是不变的。

相似文献

1
Analytical approach to mathematical modelling of the isometric contraction of the hypertrophied myocardium.肥厚心肌等长收缩数学建模的分析方法
Basic Res Cardiol. 1977 Mar-Jun;72(2-3):168-71. doi: 10.1007/BF01906356.
2
The mechanical characteristics of hypertrophied rabbit cardiac muscle in the absence of congestive heart failure: the contractile and series elastic elements.
Circ Res. 1977 Jan;40(1):20-5. doi: 10.1161/01.res.40.1.20.
3
Contracture type and fibrosis type of decreased myocardial distensibility. Different changes in elasticity of myocardium in hypoxia and hypertrophy.心肌舒张性降低的挛缩类型和纤维化类型。缺氧和肥大时心肌弹性的不同变化。
Basic Res Cardiol. 1980 Jan-Feb;75(1):244-52. doi: 10.1007/BF02001420.
4
Increased active elastic stiffness in tetanized papillary muscles from hypertrophied rabbit hearts.肥厚型兔心脏强直收缩乳头肌的主动弹性刚度增加。
Basic Res Cardiol. 1986 Sep-Oct;81(5):508-16. doi: 10.1007/BF01907757.
5
Passive stiffness of pressure-induced hypertrophied cat myocardium.压力诱导肥厚的猫心肌的被动僵硬度。
Circ Res. 1981 Jul;49(1):211-5. doi: 10.1161/01.res.49.1.211.
6
[Maximum velocity of load-free shortening Vmax, myocardial capacity and "contractility indices" in the hypertrophic myocardium].
Z Kardiol. 1976 Mar;65(4):392-400.
7
Elastic properties of normal and hypertrophied cardiac muscle.正常和肥厚心肌的弹性特性。
Fed Proc. 1980 Feb;39(2):156-61.
8
[The force-velocity relation and end systolic tension-length relation of hypertrophied myocardium in renal hypertensive rats].
Sheng Li Xue Bao. 1991 Oct;43(5):457-63.
9
Determinants of energy utilization in the activated myocardium.活化心肌中能量利用的决定因素。
Fed Proc. 1986 Oct;45(11):2597-600.
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Effect of Calcium on Slow Force Responses in Isolated Right Ventricle Preparations of Healthy and Hypertrophied Myocardium in Male and Female Rats.钙对雄性和雌性大鼠健康及肥厚心肌离体右心室标本慢力反应的影响
Bull Exp Biol Med. 2018 Jul;165(3):315-318. doi: 10.1007/s10517-018-4158-y. Epub 2018 Jul 12.

本文引用的文献

1
Effects of temperature on series elasticity and contractile element motion in heart muscle.温度对心肌串联弹性和收缩成分运动的影响。
Am J Physiol. 1969 Oct;217(4):1030-4. doi: 10.1152/ajplegacy.1969.217.4.1030.
2
Time behavior of series elasticity in cardiac muscle. Real-time measurement by controlled-length techniques.心肌串联弹性的时间行为。采用控制长度技术进行实时测量。
Circ Res. 1974 Jun;34(6):798-811. doi: 10.1161/01.res.34.6.798.
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Myocardial function in different models of cardiac hypertrophy. An attempt at correlating mechanical, biochemical, and morphological parameters.
Basic Res Cardiol. 1977 Mar-Jun;72(2-3):160-7. doi: 10.1007/BF01906355.