Protsenko Yu L, Kuznetsov D A, Lisin R V, Lukin O N, Balakin A A
Institute of Immunology and Physiology, Ural Division of the Russian Academy of Sciences, Ekaterinburg, Russia.
Bull Exp Biol Med. 2018 Jul;165(3):315-318. doi: 10.1007/s10517-018-4158-y. Epub 2018 Jul 12.
Effect of different Ca concentrations in the bathing solution [Ca] on the parameters of single isometric contraction and slow force response to stretching was studied in isolated preparations of healthy and hypertrophied myocardium of male and female Wistar rats. In all groups of experimental animals, the increase in calcium concentration was followed by a decrease in the myocardium slow response intensity. We revealed a complementary relationship between the current and medium-term systems of myocardial contractility regulation by the length of the myocardium aimed at the maintenance of the constant level during adaptation to the load. Slow responses of the hypertrophied rat heart myocardium were suppressed in comparison with those in the healthy myocardium and their intensity did not depend on animal sex.
在雄性和雌性Wistar大鼠健康及肥厚心肌的离体标本中，研究了浴液中不同钙浓度[Ca]对单次等长收缩参数以及拉伸慢力反应的影响。在所有实验组动物中，钙浓度升高后，心肌慢反应强度降低。我们揭示了心肌收缩力调节的当前和中期系统之间通过心肌长度存在互补关系，旨在在适应负荷过程中维持恒定水平。与健康心肌相比，肥厚大鼠心脏心肌的慢反应受到抑制，且其强度不依赖于动物性别。
