LOMANITZ R, HALE J M
J Bacteriol. 1963 Sep;86(3):505-9. doi: 10.1128/jb.86.3.505-509.1963.
Lomanitz, Rachel (University of Oklahoma School of Medicine, Oklahoma City) and John M. Hale. Production of delayed hypersensitivity to Cryptococcus neoformans in experimental animals. J. Bacteriol. 86:505-509. 1963.-Rabbits and guinea pigs have been sensitized to somatic, as well as whole-cell, antigens of a small-capsuled variant of Cryptococcus neoformans ODH-DV. Rabbits have also been sensitized to soma and to whole cells of a large-capsuled patient isolate. The time required for appearance of skin reactivity, after intracutaneous injection of antigenic material, indicated that the hypersensitivity developed was of the delayed type. This was subsequently demonstrated in both rabbits and guinea pigs by passive transfer of the hypersensitivity to normal animals. Efforts to transfer the skin sensitivity to normal rabbits with serum from sensitized animals were unsuccessful, indicating that humoral antibodies are not involved. Preliminary studies suggest that the sensitizing antigen resides in the cell wall and is highly specific.
罗曼尼茨，雷切尔（俄克拉荷马大学医学院，俄克拉荷马城）和约翰·M·黑尔。实验动物对新型隐球菌迟发型超敏反应的产生。《细菌学杂志》86:505 - 509。1963年。——兔子和豚鼠已被新型隐球菌ODH - DV小荚膜变种的体细胞抗原以及全细胞抗原致敏。兔子也已被一大荚膜患者分离株的体细胞和全细胞致敏。皮内注射抗原物质后皮肤反应性出现所需的时间表明，所产生的超敏反应是迟发型的。随后在兔子和豚鼠中通过将超敏反应被动转移到正常动物身上得到了证实。用致敏动物的血清将皮肤敏感性转移到正常兔子身上的尝试未成功，表明体液抗体未参与其中。初步研究表明，致敏抗原存在于细胞壁中且具有高度特异性。
