CAMPBELL C H
J Bacteriol. 1963 Sep;86(3):593-7. doi: 10.1128/jb.86.3.593-597.1963.
Campbell, Charles H. (Plum Island Animal Disease Laboratory, Greenport, N.Y.). Influence of tissue culture passage on virulence of foot-and-mouth disease virus for mother mice. J. Bacteriol. 86:593-597. 1963.-Foot-and-mouth disease virus serially passaged in bovine cell cultures was more lethal for mother mice than the parent virus from infected steers. In tests with virus from several pools of bovine tongue tissue, only 0 to 20% of the mice died. Serial passage of such virus in primary calf-kidney cell cultures progressively increased the lethality of the virus. By the eighth passage, after which no further appreciable increase was observed, the mortality was 60%. As the lethal capability of this virus population increased, the average time required for it to produce death decreased.
坎贝尔，查尔斯·H.（纽约州格林波特普拉姆岛动物疾病实验室）。组织培养传代对口蹄疫病毒对母鼠毒力的影响。《细菌学杂志》86:593 - 597。1963年。——在牛细胞培养物中连续传代的口蹄疫病毒对母鼠的致死性比来自感染公牛的亲本病毒更强。在用来自几批牛舌组织的病毒进行的试验中，只有0%至20%的小鼠死亡。这种病毒在原代犊牛肾细胞培养物中连续传代逐渐增加了病毒的致死性。到第八代时，此后未观察到进一步明显增加，死亡率为60%。随着该病毒群体致死能力的增加，其导致死亡所需的平均时间缩短。
