循环中抗原 - 抗体复合物及其他大分子在血管内定位的研究。II. 发病机制与药效学研究。
STUDIES ON THE LOCALIZATION OF CIRCULATING ANTIGEN-ANTIBODY COMPLEXES AND OTHER MACROMOLECULES IN VESSELS. II. PATHOGENETIC AND PHARMACODYNAMIC STUDIES.
作者信息
COCHRANE C G
出版信息
J Exp Med. 1963 Oct 1;118(4):503-13. doi: 10.1084/jem.118.4.503.
Abstract
Localization of circulating antigen-antibody complexes in vessels of guinea pigs by means of anaphylactic shock was found to be mediated by histamine that was released at the time of anaphylaxis. The source of the histamine may have been the mast cell as noted in studies employing a direct attack on the mast cells by octylamine. Platelets played apparently little to no role in guinea pigs in the anaphylactic deposition of circulating complexes. Rat anaphylatoxin was found to cause vascular localization and symptoms of anaphylaxis identical with that brought about by antigen-antibody anaphylaxis. This also was found to be dependent upon the release of histamine. Antibody against Forssman antigen in the vessel walls of the guinea pigs also led to deposition of circulating complexes. This was found not to be histamine dependent. The possible role of local increase in vascular permeability in certain experimental disease states in the localization of circulating complexes is discussed.
摘要
通过过敏休克发现，豚鼠血管中循环抗原 - 抗体复合物的定位是由过敏反应时释放的组胺介导的。组胺的来源可能是肥大细胞，如在使用辛胺直接攻击肥大细胞的研究中所指出的那样。在豚鼠中，血小板在循环复合物的过敏反应沉积中显然几乎没有作用。发现大鼠过敏毒素会导致血管定位和与抗原 - 抗体过敏反应引起的症状相同的过敏反应症状。这也被发现依赖于组胺的释放。豚鼠血管壁中针对福斯曼抗原的抗体也会导致循环复合物的沉积。发现这并不依赖于组胺。讨论了局部血管通透性增加在某些实验性疾病状态下在循环复合物定位中的可能作用。
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