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J Exp Med. 1963 Oct 1;118(4):515-26. doi: 10.1084/jem.118.4.515.
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1
[Morphological findings in Zieve's syndrome (author's transl)].齐夫综合征的形态学表现（作者译）
Z Rechtsmed. 1975 Dec 10;76(4):335-41. doi: 10.1007/BF02114693.

本文引用的文献

1
Antituberculous effect of certain surface-active polyoxyethylene ethers in mice.某些表面活性聚氧乙烯醚对小鼠的抗结核作用。
Nature. 1951 Jul 28;168(4265):150-3. doi: 10.1038/168150a0.
2
The influence of intravenously administered surface-active agents on the development of experimental atherosclerosis in rabbits.静脉注射表面活性剂对家兔实验性动脉粥样硬化发展的影响。
J Exp Med. 1951 Apr 1;93(4):385-98. doi: 10.1084/jem.93.4.385.
3
Effect of Lipomul infusion on plasma lipolytic activity. Characterization and partial purification of a post-Lipomul lipase and its role in changing the electrophoretic mobility of serum lipoproteins.脂肪乳剂输注对血浆脂解活性的影响。脂肪乳剂后脂肪酶的特性、部分纯化及其在改变血清脂蛋白电泳迁移率中的作用。
J Lab Clin Med. 1962 Apr;59:558-67.
4
Heparin, the clearing factor lipase, and fat transport.肝素、清除因子脂肪酶与脂肪转运
Pharmacol Rev. 1960 Jun;12:241-63.
5
The role of liver and spleen in the metabolism of intravenously injected fat in rabbits.肝脏和脾脏在兔静脉注射脂肪代谢中的作用
J Exp Med. 1961 Dec 1;114(6):1035-47. doi: 10.1084/jem.114.6.1035.
6
Microdetermination of long-chain fatty acids in plasma and tissues.血浆和组织中长链脂肪酸的微量测定
J Biol Chem. 1960 Sep;235:2595-9.
7
Triton hyperlipemia in dogs. I. In vitro effects of the detergent on serum lipoproteins and chylomcrons.犬类的 Triton 高脂血症。I. 去污剂对血清脂蛋白和乳糜微粒的体外作用。
J Exp Med. 1961 Apr 1;113(4):735-57. doi: 10.1084/jem.113.4.735.
8
Effect of triton on rate of removal of palmitate-1-C14 from serum.曲拉通对血清中棕榈酸-1-C14清除率的影响。
Am J Physiol. 1960 Nov;199:833-5. doi: 10.1152/ajplegacy.1960.199.5.833.
9
Assimilation and dissimilation of fatty acids by the rat liver.大鼠肝脏对脂肪酸的同化与异化作用。
Am J Physiol. 1959 Jun;196(6):1238-41. doi: 10.1152/ajplegacy.1959.196.6.1238.
10
Transport of fatty acids.脂肪酸的转运
Physiol Rev. 1958 Oct;38(4):585-630. doi: 10.1152/physrev.1958.38.4.585.

注射脂肪乳剂和肝素的家兔惊厥综合征

CONVULSIVE SYNDROME IN RABBITS INJECTED WITH FAT EMULSION AND HEPARIN.

作者信息

VANDENBOSCH J, BILLIAU A

出版信息

J Exp Med. 1963 Oct 1;118(4):515-26. doi: 10.1084/jem.118.4.515.

DOI:10.1084/jem.118.4.515
PMID:14067903
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2137664/
Abstract

Functionally hepatectomized rabbits showed convulsions and coma within 2 hours after the intravenous injection of fat emulsion and heparin. Intravenous injection of the detergent triton prevented this syndrome, if given before the fat emulsion and heparin, and reversed it if given subsequently. Extremely high plasma non-esterified fatty acid levels were noted in rabbits showing the convulsive syndrome, but not in animals that received the detergent. The mechanism of the convulsions probably includes the toxicity of high amounts of non-esterified fatty acids.

摘要

功能性肝切除的兔子在静脉注射脂肪乳剂和肝素后2小时内出现惊厥和昏迷。如果在注射脂肪乳剂和肝素之前静脉注射去污剂曲通，可以预防这种综合征；如果在之后注射，则可使其逆转。出现惊厥综合征的兔子血浆中非酯化脂肪酸水平极高，但接受去污剂的动物则没有。惊厥的机制可能包括大量非酯化脂肪酸的毒性作用。