KELLNER A, CORRELL J W, LADD A T
J Exp Med. 1951 Apr 1;93(4):385-98. doi: 10.1084/jem.93.4.385.
A study was made of the relationship of blood lipids to the development of experimental atherosclerosis. Rabbits fed a diet containing cholesterol were found to develop hyperlipemia characterized by a great increase in blood cholesterol and a much lesser increase in blood phospholipids; after several weeks they manifested conspicuous atherosclerosis of the aorta, as has often been observed by others. Comparable rabbits fed the same diets containing added cholesterol were given in addition repeated intravenous injections of the surface-active agents Tween 80 and Triton A20; these animals developed hyperlipemia which was characterized by a great increase in blood cholesterol and an equivalent or even greater increase in phospholipids, and they had much less atherosclerosis than did the control rabbits fed cholesterol alone. In further experiments it was observed that repeated intravenous injections of Tween 80 did not result in resorption of previously induced atherosclerosis in rabbits. The findings are discussed in relation to the pathogenesis of natural and experimental atherosclerosis.
对血脂与实验性动脉粥样硬化发展之间的关系进行了一项研究。发现喂食含胆固醇饮食的兔子会出现高脂血症，其特征是血液胆固醇大幅增加，而血液磷脂增加较少；几周后，它们表现出主动脉明显的动脉粥样硬化，这是其他人经常观察到的情况。给喂食相同含添加胆固醇饮食的类似兔子额外反复静脉注射表面活性剂吐温80和 Triton A20；这些动物出现了高脂血症，其特征是血液胆固醇大幅增加，磷脂增加相当或甚至更大，并且它们的动脉粥样硬化比仅喂食胆固醇的对照兔子少得多。在进一步的实验中观察到，反复静脉注射吐温80不会导致兔子先前诱导的动脉粥样硬化的吸收。结合自然和实验性动脉粥样硬化的发病机制对这些发现进行了讨论。
