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革兰氏阴性菌“天然”抗体与γ-1-巨球蛋白的关联

ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE GAMMA-1-MACROGLOBULINS.

作者信息

MICHAEL J G, ROSEN F S

出版信息

J Exp Med. 1963 Oct 1;118(4):619-26. doi: 10.1084/jem.118.4.619.

DOI:10.1084/jem.118.4.619
PMID:14067909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2137662/
Abstract

"Natural" antibodies to representative species of Enterobacteriaceae were found to be principally associated with the gamma(1)-macroglobulin prepared from Cohn fraction III-I of pooled human plasma. The amount of antibodies present was estimated by measuring the bactericidal, hemagglutinating, mouse-protective, and opsonophagocytic activities of this fraction. Comparison with the antibody activity of gamma(2)-globulin of Cohn fraction II showed that up to 100 times more antibody activity on a weight basis was present in the macroglobulin fraction. These findings suggest that differences between natural and immune antibody result from the physicochemical properties of 2 different classes of immune globulin.

摘要

已发现针对肠杆菌科代表性菌种的“天然”抗体主要与从混合人血浆的科恩Ⅲ - 1组分制备的γ(1)-巨球蛋白相关。通过测量该组分的杀菌、血凝、小鼠保护和调理吞噬活性来估计其中存在的抗体量。与科恩Ⅱ组分的γ(2)-球蛋白的抗体活性比较表明，按重量计算，巨球蛋白组分中的抗体活性高出多达100倍。这些发现表明，天然抗体和免疫抗体之间的差异源于两类不同免疫球蛋白的物理化学性质。

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