豚鼠对淋球菌感染的免疫发展和被动传递。
Development and passive transfer of immunity to gonococcal infection in Guinea pigs.
机构信息
Center for Disease Control, Atlanta, Georgia 30333.
出版信息
Infect Immun. 1974 Nov;10(5):1040-3. doi: 10.1128/iai.10.5.1040-1043.1974.
Abstract
Gonococcal infections of relatively long duration were produced in guinea pigs with minimal infective doses ranging from 10(1) to 10(2) colony-forming units. After spontaneous eradication and upon rechallenge with >/=10(8) gonococcal colony-forming units, guinea pigs were refractory to infection. Serum from these guinea pigs was bactericidal in vitro and protected virgin guinea pigs from in vivo challenge. The 7S peak, but not the 19S peak, from gel filtered immune serum demonstrated both bactericidal and passive protective properties. In vitro bactericidal activity of whole immune serum and its 7S peak was abolished after heating at 56 C for 30 min. The in vivo protective ability of the 7S peak was not abolished after heating.
摘要
用 10(1)到 10(2)个集落形成单位的最小感染剂量，在豚鼠中产生了持续时间相对较长的淋球菌感染。在自发清除后，用>/=10(8)个淋球菌集落形成单位再次攻击时，豚鼠对感染具有抗性。这些豚鼠的血清在体外具有杀菌作用，并能保护处女豚鼠免受体内攻击。从凝胶过滤免疫血清中得到的 7S 峰，但不是 19S 峰，具有杀菌和被动保护作用。整个免疫血清及其 7S 峰的体外杀菌活性在 56°C 加热 30 分钟后被消除。7S 峰的体内保护能力在加热后并未丧失。
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本文引用的文献
1
Lymphocyte transformation in repeated gonococcal urethritis.
Infect Immun. 1970 Nov;2(5):655-8. doi: 10.1128/iai.2.5.655-658.1970.
2
ASSOCIATION OF "NATURAL" ANTIBODIES TO GRAM-NEGATIVE BACTERIA WITH THE GAMMA-1-MACROGLOBULINS.
J Exp Med. 1963 Oct 1;118(4):619-26. doi: 10.1084/jem.118.4.619.
3
NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.
J Bacteriol. 1963 Jun;85(6):1274-9. doi: 10.1128/jb.85.6.1274-1279.1963.
4
Properties of guinea pig 7S antibodies. III. Identification of antibodies involved in complement fixation and hemolysis.
J Exp Med. 1963 Jun 1;117(6):965-81. doi: 10.1084/jem.117.6.965.
5
[A micro-method of immuno-electrophoresis].
Int Arch Allergy Appl Immunol. 1955;7(2):103-10.
6
Transfer of gonococcal urethritis from man to chimpanzee. An animal model for gonorrhea.
JAMA. 1971 Jun 7;216(10):1612-4.
7
Reactivity of two gonococcal antigens in an automated microhemagglutination procedure.
Appl Microbiol. 1970 Dec;20(6):907-9. doi: 10.1128/am.20.6.907-909.1970.
8
Gonorrhoea in the chimpanzee. Infection with laboratory-passed gonococci and by natural transmission.
Br J Vener Dis. 1972 Jun;48(3):177-8. doi: 10.1136/sti.48.3.177.
9
Implantation and use of a subcutaneous culture chamber in laboratory animals.
Lab Anim Sci. 1973 Feb;23(1):105-6.
10
Paradox of the immune response to uncomplicated gonococcal urethritis.
N Engl J Med. 1973 Nov 29;289(22):1170-4. doi: 10.1056/NEJM197311292892205.
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