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一种存在于淋巴结细胞中、能够增加血管通透性的因子。一种可能的迟发反应介质。

A FACTOR CAPABLE OF INCREASING VASCULAR PERMEABILITY PRESENT IN LYMPH NODE CELLS. A POSSIBLE MEDIATOR OF THE DELAYED REACTION.

作者信息

WILLOUGHBY D A, BOUGHTON B, SCHILD H O

出版信息

Immunology. 1963 Sep;6(5):484-98.

PMID:14069726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423277/
Abstract

A soluble extract from guinea-pig lymph node cells (LPF) has been found to increase vascular permeability in the skin of the rat. The active substance has been differentiated from histamine, 5-hydroxytryptamine, bradykinin, substance P, kallikrein and the globulin permeability factors from rat and guinea-pig serum by means of parallel quantitative assays. LPF was present in both sensitized and non-sensitized guinea-pig lymph node cells and in lymph node cells from rats and mice. LPF also increased vascular permeability in the skin of guinea-pigs, mice and rabbits. The possible importance of this factor in the mechanism of the delayed reactions is discussed.

摘要

已发现豚鼠淋巴结细胞的一种可溶性提取物（LPF）可增加大鼠皮肤的血管通透性。通过平行定量测定，已将活性物质与组胺、5-羟色胺、缓激肽、P物质、激肽释放酶以及大鼠和豚鼠血清中的球蛋白通透性因子区分开来。LPF存在于致敏和未致敏的豚鼠淋巴结细胞以及大鼠和小鼠的淋巴结细胞中。LPF还可增加豚鼠、小鼠和兔子皮肤的血管通透性。文中讨论了该因子在迟发型反应机制中的可能重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7b/1423277/3e6b5cbe0d64/immunology00448-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7b/1423277/6868e5becd16/immunology00448-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7b/1423277/3e6b5cbe0d64/immunology00448-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7b/1423277/6868e5becd16/immunology00448-0072-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee7b/1423277/3e6b5cbe0d64/immunology00448-0074-a.jpg

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