Förstl H, Burns A, Cairns N, Luthert P, Lantos P, Levy R
Section of Old Age Psychiatry, Institute of Psychiatry, London, UK.
Nervenarzt. 1992 Sep;63(9):566-74.
The diagnosis of Alzheimer's disease (AD) was verified at post-mortem examination in 46 patients (9 male: 37 female; mean age 83.6 +/- 6.5 years) from a prospective clinical study. Compared to 10 age-matched controls, the total AD group showed a significant neuronal loss in the locus coeruleus, dorsal raphe nucleus, substantia nigra and in the basal nucleus of Meynert. Twelve patients (1 male: 11 female) had experienced symptoms of depression. These patients had significantly lower neuronal counts in the locus coeruleus, but less severe cell loss in the basal nucleus of Meynert compared to the AD patients without depression.
在一项前瞻性临床研究中，46例患者（9例男性，37例女性；平均年龄83.6±6.5岁）在尸检时确诊为阿尔茨海默病（AD）。与10例年龄匹配的对照组相比，AD患者组在蓝斑、中缝背核、黑质和Meynert基底核均出现了明显的神经元丢失。12例患者（1例男性，11例女性）曾出现过抑郁症状。与无抑郁症状的AD患者相比，这些患者蓝斑中的神经元数量明显减少，但Meynert基底核中的细胞丢失程度较轻。
