Suzuki S, Mori A
Department of Neuroscience, Okayama University Medical School, Japan.
Neurochem Res. 1992 Jul;17(7):693-8. doi: 10.1007/BF00968007.
Tyrosine, tryptophan, and their metabolites in the brain of ddY, non-stimulated El (El (-)), and stimulated El (El (+)) mice were measured using the three dimensional HPLC. The tryptophan content was lower in El (+) than ddY and El (-) mice. The 5-hydroxytryptophan content was much higher in both El groups. The serotonin content of El (+) was higher than that of ddY and El (-) mice. The kynurenine content was remarkably high in the El mice. The dopamine content was lower in El (-) than in ddY mice, whereas it was greater in El (+) than in El (-) mice. The norepinephrine showed higher levels in El (+) mice. These facts suggest that El mice possess congenital metabolic abnormalities of tryptophan and tyrosine and that kynurenine may play an important role as convulsant in El mice seizures along with changes in serotonin, dopamine, and norepinephrine that are inhibitory agents and responded to the repetitive convulsions.
使用三维高效液相色谱法测量了ddY小鼠、未受刺激的E1（E1(-)）小鼠和受刺激的E1（E1(+)）小鼠大脑中的酪氨酸、色氨酸及其代谢产物。E1(+)小鼠的色氨酸含量低于ddY小鼠和E1(-)小鼠。两个E1组的5-羟色氨酸含量都高得多。E1(+)小鼠的血清素含量高于ddY小鼠和E1(-)小鼠。E1小鼠的犬尿氨酸含量显著较高。E1(-)小鼠的多巴胺含量低于ddY小鼠，而E1(+)小鼠的多巴胺含量高于E1(-)小鼠。去甲肾上腺素在E1(+)小鼠中的水平较高。这些事实表明，E1小鼠存在色氨酸和酪氨酸的先天性代谢异常，并且犬尿氨酸可能在E1小鼠癫痫发作中作为惊厥剂发挥重要作用，同时血清素、多巴胺和去甲肾上腺素这些抑制剂发生了变化，并对重复性惊厥产生了反应。
