[降钙素的利尿作用：对亨利氏袢升支钠重吸收抑制作用的证明]
[Diuretic action of calcitonin: demonstration of an inhibiting effect on sodium reabsorption in the ascending limb of Henlé's loop].
作者信息
Simonnet G, Laparra J, Blanquet P
出版信息
C R Seances Soc Biol Fil. 1976;170(6):1194-200.
PMID:140734
Abstract
It was found that calcitonin (porcine) at the dose: 4 I.U. MRC./kg/hr (i.v.), in the rabbit, increased the diuresis and oxmolal excretion, and simultaneously decreased free-water reabsorption and urinary osmolality. The results suggest that calcitonin acts by inhibiting sodium reabsorption in the ascending limb of Henl's loop. This hypothesis was confirmed by renal autoradiography study with 22Na.
摘要
结果发现，给家兔静脉注射剂量为4国际单位MRC/千克/小时的（猪）降钙素后，其利尿和氧摩尔排泄增加，同时自由水重吸收和尿渗透压降低。结果表明，降钙素的作用是抑制亨利氏袢升支中的钠重吸收。用22Na进行的肾脏放射自显影研究证实了这一假说。
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