Stephanou A, Melino G, Knight R A, Annicchiarico-Petruzzelli M, Sarlis N J, Finazzi-Agro A, Lightman S L
Department of Neuroendocrinology, Charing Cross and Westminster Medical School, Charing Cross Hospital, London, UK.
Neuropeptides. 1992 Sep;23(1):45-9. doi: 10.1016/0143-4179(92)90009-l.
Two cell clones [BE(2)-C and BE(2)-M17] derived from the human neuroblastoma cell line SK-N-BE(2) express corticotrophin-releasing hormone as well as interleukin-6 mRNA. Both genes are overexpressed, although with a different time course, following exposure to 5 microM retinoic acid, in parallel to the induction of neuroblastic differentiation. On the contrary, we are unable to detect interleukin-1 beta mRNA in these cell lines. Both cytokines are known to increase hypothalamic CRH mRNA. The production of cytokines and neuropeptides by neuroblastoma cells indicate a complex dialogue between tumour cells and anti-tumour immunity.
源自人神经母细胞瘤细胞系SK-N-BE(2)的两个细胞克隆[BE(2)-C和BE(2)-M17]表达促肾上腺皮质激素释放激素以及白细胞介素-6信使核糖核酸。在暴露于5微摩尔视黄酸后，这两个基因均过度表达，尽管时间进程不同，且与神经母细胞分化的诱导同时发生。相反，我们在这些细胞系中无法检测到白细胞介素-1β信使核糖核酸。已知这两种细胞因子都会增加下丘脑促肾上腺皮质激素释放激素信使核糖核酸。神经母细胞瘤细胞产生细胞因子和神经肽表明肿瘤细胞与抗肿瘤免疫之间存在复杂的对话。
