Stephanou A, Knight R A, Annicchiarico-Petruzzelli M, Finazzi-Agrò A, Lightmann S L, Melino G
Department of Neuroendocrinology, Charing Cross Hospital, London, UK.
Funct Neurol. 1992 Mar-Apr;7(2):129-33.
We report the expression of different interleukins (IL) in four human glioblastoma and neuroblastoma cell lines. The glioblastoma cell line LI, expresses IL-1 beta and IL-6 mRNA, though not IL-2 and IL-4. The expression of the former gene is modulated by retinoic acid. Two cell clones [BE(2)-C and BE(2)-M17] as well as the neuroblastoma cell line SK-N-BE(2), from which both clones were derived, express IL-6 mRNA, but not IL-1 beta, IL-2 or IL-4. Both IL-1 beta and IL-6 cytokines are known to increase hypothalamic CRH mRNA, a gene reported to be expressed in all these cell lines. The production of both cytokines and neuropeptides indicates a complex dialogue between tumour cells and anti-tumour immunity.
我们报告了四种人类胶质母细胞瘤和神经母细胞瘤细胞系中不同白细胞介素（IL）的表达情况。胶质母细胞瘤细胞系LI表达IL-1β和IL-6 mRNA，但不表达IL-2和IL-4。前一个基因的表达受视黄酸调节。两个细胞克隆[BE(2)-C和BE(2)-M17]以及源自它们的神经母细胞瘤细胞系SK-N-BE(2)表达IL-6 mRNA，但不表达IL-1β、IL-2或IL-4。已知IL-1β和IL-6细胞因子均会增加下丘脑促肾上腺皮质激素释放激素（CRH）mRNA的表达，据报道该基因在所有这些细胞系中均有表达。细胞因子和神经肽的产生表明肿瘤细胞与抗肿瘤免疫之间存在复杂的相互作用。
