大鼠肝脏组织的半乳糖代谢：年龄的影响。

GALACTOSE METABOLISM BY RAT LIVER TISSUE: INFLUENCE OF AGE.

作者信息

SEGAL S, ROTH H, BERTOLI D

出版信息

Science. 1963 Dec 6;142(3597):1311-3. doi: 10.1126/science.142.3597.1311.

DOI:10.1126/science.142.3597.1311

Abstract

The metabolism of galactose by liver tissue from fetal, new-born, pre-adult, and adult rats was studied in vitro by determining the extent of conversion of galactose to CO(2) and the disappearance of the sugar from the incubation medium. Results indicate that the utilization of galactose by liver tissue decreases as the organism grows older. The explanation of the tendency of patients with congenital galactosemia to improve symptomatically with age on the basis of "maturation" of galactose metabolizing pathways in their livers does not appear to be consistent with these observations.

摘要

通过测定半乳糖向二氧化碳的转化程度以及培养液中半乳糖的消失情况，对胎鼠、新生鼠、未成年鼠和成年鼠肝脏组织对半乳糖的代谢进行了体外研究。结果表明，随着机体年龄增长，肝脏组织对半乳糖的利用率降低。基于先天性半乳糖血症患者肝脏中半乳糖代谢途径“成熟”而出现的症状随年龄增长有所改善这一趋势，其解释似乎与这些观察结果不一致。