Bertrand H, Kohout J
Can J Genet Cytol. 1977 Mar;19(1):81-91. doi: 10.1139/g77-010.
The mitochondrial cytochrome aa3 and b deficiencies of the [poky] cytoplasmic mutant of Neurospora crassa are partially suppressed by mutant alleles of any one of six nuclear genes, namely sup-1, sup-3, sup-4, sup-5, sup-10 and sup-14. The suppressor-induced increases in the concentration of both cytochromes are detected in the mitochondria from exponentially growing [poky] cultures, and, thus, are clearly distinguishable from the age-dependent changes in the cytochrome system that occur in cultures that approach, or have reached, the stationary phase of growth. The relative amounts of mitochondrial cytochromes aa3 and b show a direct correlation with the relative efficiency of the various sup genes as suppressors of the slow-growth phenotype of [poky]. Since [poky] is defective in mitochondrial protein synthesis due to a lack of 30 S mitochondrial ribosomal subunits, it is proposed that the six suppressors promote the assembly of functional mitochondrial ribosomes.
粗糙脉孢菌的细胞质突变体[迟缓型]的线粒体细胞色素aa3和b缺陷，可被六个核基因（即sup-1、sup-3、sup-4、sup-5、sup-10和sup-14）中任何一个的突变等位基因部分抑制。在指数生长的[迟缓型]培养物的线粒体中，可检测到抑制因子诱导的两种细胞色素浓度增加，因此，这与接近或已达到生长稳定期的培养物中细胞色素系统随年龄的变化明显不同。线粒体细胞色素aa3和b的相对含量与各种sup基因作为[迟缓型]生长缓慢表型抑制因子的相对效率直接相关。由于[迟缓型]因缺乏30S线粒体核糖体亚基而在线粒体蛋白质合成中存在缺陷，因此有人提出这六个抑制因子促进功能性线粒体核糖体的组装。
