CONEN P E, MURPHY E G, DONOHUE W L
Can Med Assoc J. 1963 Nov 9;89(19):983-6.
Examination by light and electron microscopy of more than 100 muscle biopsies revealed one very unusual case. A 4-year-old boy with non-progressive muscle weakness and hypotonia was found to have small particles, termed "myogranules", in many muscle fibres from two gastrocnemius biopsies. Paraffin sections and thin sections of plastic-embedded muscle showed that the rod-shaped myogranules measured between 0.1 and 5 microns in length, and were usually orientated in the long axis of the fibre. Normal cross-striations could not be seen in areas occupied by myogranules, although adjacent parts of the same fibre were normal. Electron micrographs showed myofilaments running through the myogranules and a periodicity similar to sections of recrystallized muscle protein paramyosin. It is possible that this child has a disturbance of muscle proteins.
对100多份肌肉活检样本进行光学显微镜和电子显微镜检查后，发现了一个非常特殊的病例。一名患有非进行性肌无力和肌张力减退的4岁男孩，在取自双侧腓肠肌的活检样本中的许多肌纤维中发现了被称为“肌颗粒”的小颗粒。石蜡切片和塑料包埋肌肉的薄片显示，杆状肌颗粒长度在0.1至5微米之间，通常沿肌纤维的长轴排列。在肌颗粒占据的区域看不到正常的横纹，尽管同一肌纤维的相邻部分是正常的。电子显微镜照片显示肌丝贯穿肌颗粒，其周期性与重结晶肌肉蛋白副肌球蛋白切片相似。这个孩子有可能存在肌肉蛋白紊乱的情况。
