Smetana K, Daskal Y, Gyorkey F, Gyorkey P, Lehane D E, Rudolph A H, Busch H
Cancer Res. 1977 Jul;37(7 Pt 1):2036-42.
Sézary cells were studied in the peripheral blood and characteristic skin lesions of the Sézary syndrome and mycosis fungoides by transmission electron microscopy to obtain more information on their nuclear and nucleolar ultrastructure. Sézary cells contain nucleoli with nucleolonemas or ring-shaped nucleoli similar to those of lymphoblasts and mature lymphocytes. "Maturation asynchrony" of the nucleolus and cytoplasm was evident in some cells that contain large numbers of ribosomes and ring-shaped nucleoli and in other cells that contain nucleoi with nucleolonemas and few ribosomes. The maturation asynchrony of the nucleolus and the cytoplasm, the presence of mitochondrion-like inclusion bodies in the nucleus, and fusion of mitochondria with the nucleus in Sézary cells are ultrastructural abnormalities of this neoplastic lymphocytic variant. The presence of the intranuclear "mitochondrion-like" inclusion body and nuclear rodlets in Sézary cells were exceptional findings.
通过透射电子显微镜对蕈样肉芽肿综合征和蕈样霉菌病的外周血及特征性皮肤损害中的 Sézary 细胞进行研究，以获取更多关于其细胞核和核仁超微结构的信息。Sézary 细胞含有核仁丝的核仁或与淋巴母细胞和成熟淋巴细胞相似的环形核仁。在一些含有大量核糖体和环形核仁的细胞以及其他含有核仁丝且核糖体较少的细胞中，核仁与细胞质的“成熟不同步”现象明显。Sézary 细胞中核仁与细胞质的成熟不同步、细胞核内出现线粒体样包涵体以及线粒体与细胞核融合，是这种肿瘤性淋巴细胞变体的超微结构异常。Sézary 细胞中核内“线粒体样”包涵体和核小体的存在是特殊发现。
