Tykocinski M, Schinella R, Greco M A
Arch Pathol Lab Med. 1984 May;108(5):387-91.
Five patients with advanced disseminated mycosis fungoides were studied, using light and electron microscopy. All had lesions with large pleomorphic cells by light microscopy. In three of the patients, nonlymphoid tissue was studied, including pericardium, epididymis, and small intestine. All areas selected for ultrastructural study showed large pleomorphic cells. We conclude that these represent poorly differentiated lymphoid cells derived from Sézary lymphocytes. This is based on nuclear and organelle similarities between the Sézary and pleomorphic cells, as well as the demonstration of intermediate forms.
对5例晚期播散性蕈样肉芽肿患者进行了光镜和电镜研究。所有患者的病变在光镜下均可见大的多形性细胞。其中3例患者的非淋巴组织也进行了研究，包括心包、附睾和小肠。所有选择进行超微结构研究的区域均显示有大的多形性细胞。我们得出结论，这些细胞代表源自Sezary淋巴细胞的低分化淋巴细胞。这是基于Sezary细胞和多形性细胞之间的核及细胞器相似性，以及中间形式的证实。
