Hof P R, Charpiot A, Delacourte A, Buée L, Purohit D, Perl D P, Bouras C
Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY 10029.
Neurosci Lett. 1992 May 11;139(1):10-4. doi: 10.1016/0304-3940(92)90846-y.
Postencephalitic parkinsonism is characterized neuropathologically by severe loss of pigmented neurons in the substantia nigra and the presence of high densities of neurofibrillary tangles in several brainstem structures. In 5 cases of postencephalitic parkinsonism, we observed that the neurofibrillary tangle distribution in the cerebral cortex predominated in the hippocampus and entorhinal cortex. In the prefrontal and inferior temporal cortex, neurofibrillary tangles were preferentially localized in layers II and III. This pattern contrasts with the neurofibrillary tangle distribution observed in neocortical areas of Alzheimer's disease cases, where neurofibrillary tangles are denser in layer V than in layer III. These results suggest that specific elements of the cortical circuitry might be differentially affected in postencephalitic parkinsonism as compared to Alzheimer's disease, and that cortical involvement is likely to be a common feature of this condition.
脑炎后帕金森综合征的神经病理学特征是黑质中色素神经元严重缺失，以及在几个脑干结构中存在高密度的神经原纤维缠结。在5例脑炎后帕金森综合征患者中，我们观察到大脑皮质中的神经原纤维缠结分布在海马体和内嗅皮质中占主导地位。在前额叶和颞下回皮质中，神经原纤维缠结优先定位于第II层和第III层。这种模式与阿尔茨海默病患者新皮质区域中观察到的神经原纤维缠结分布形成对比，在阿尔茨海默病中，神经原纤维缠结在第V层比在第III层更密集。这些结果表明，与阿尔茨海默病相比，脑炎后帕金森综合征中皮质回路的特定元素可能受到不同影响，并且皮质受累可能是这种疾病的一个共同特征。
