鞘内注射咪达唑仑与鞘内注射吗啡治疗口面部伤害感受：一项在大鼠身上的实验研究
Intrathecal midazolam versus intrathecal morphine in orofacial nociception: an experimental study in rats.
作者信息
Aigouy L, Fondras J C, Pajot J, Schoeffler P, Woda A
机构信息
Laboratoire de Physiologie Orofaciale, U.E.R. Odontologie, Clermont-Ferrand, France.
出版信息
Neurosci Lett. 1992 May 11;139(1):97-9. doi: 10.1016/0304-3940(92)90866-6.
The antinociceptive properties of intrathecal midazolam (15 and 30 micrograms) and intrathecal morphine (30 micrograms) were compared using an adaptation of the formalin test to the orofacial region in rats. Both midazolam and morphine were effective in reducing the nociceptive response of the second phase of this biphasic pain test. Only midazolam (30 micrograms) reduced also the first phase. These results confirm the existence of analgesic properties of midazolam in the case of long-lasting pain.
通过对福尔马林试验进行改良，使其适用于大鼠的口面部区域，比较了鞘内注射咪达唑仑（15微克和30微克）和鞘内注射吗啡（30微克）的抗伤害感受特性。咪达唑仑和吗啡在减轻这种双相疼痛试验第二阶段的伤害性反应方面均有效。只有咪达唑仑（30微克）也减轻了第一阶段的反应。这些结果证实了在持久疼痛情况下咪达唑仑具有镇痛特性。
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