Facchinetti F, Virgili M, Migani P, Barnabei O, Contestabile A
Department of Biology, University of Bologna, Italy.
Neurosci Lett. 1992 Jun 8;140(1):59-62. doi: 10.1016/0304-3940(92)90681-v.
The activity of ornithine decarboxylase (ODC), the key enzyme of polyamine biosynthesis, dramatically increases after different types of brain injuries. The role of this induction is still unclear. We report here data on the temporal pattern of ODC induction caused by the excitotoxin kainic acid. After systemic administration, ODC activity increases severalfold peaking at 8 h in the prefrontal cortex and at 16 h in the olfactory cortex and hippocampus. After intrastriatal injection, the peak of induction is reached at 32 h, while a smaller and more transient increase is also observed in the contralateral, saline-injected striatum. We suggest that ODC induction is initially linked to overactivation of neural circuits and, later on, to the development of widespread neural damage.
鸟氨酸脱羧酶（ODC）是多胺生物合成的关键酶，在不同类型的脑损伤后其活性会显著增加。这种诱导作用的机制仍不清楚。我们在此报告由兴奋性毒素海人酸引起的ODC诱导的时间模式数据。全身给药后，前额叶皮质中ODC活性在8小时达到峰值，增加了几倍，而在嗅皮质和海马体中在16小时达到峰值。纹状体内注射后，诱导峰值在32小时达到，而在对侧注射生理盐水的纹状体中也观察到较小且更短暂的增加。我们认为，ODC的诱导最初与神经回路的过度激活有关，随后与广泛的神经损伤发展有关。
