Ciani E, Contestabile A
Department of Biology, University of Bologna, Italy.
Brain Res Dev Brain Res. 1993 Feb 19;71(2):258-60. doi: 10.1016/0165-3806(93)90178-d.
The induction of brain ornithine decarboxylase (ODC) as a consequence of systemic kainic acid administration was studied in the hippocampus and the olfactory cortex-amygdala area of 10-day-old rat pups and 30-day-old young rats. In pups, ODC levels were moderately increased (plus 50-80%) 4 h after kainic acid administration, coming back quickly to control levels afterwards. In young rats, instead, ODC levels were dramatically increased by 17-25-fold, 16 h after kainic acid administration and decreased towards basal levels 48-72 h after injection. The present results suggest that the process of excitotoxic ODC induction can be split in two phases: a first phase characterized by moderate induction and essentially linked to the overstimulation of brain circuits and a second phase, during which a dramatic enzyme stimulation is accompanied by the appearance of neurodegenerative pathology.
研究了全身给予红藻氨酸后，10日龄幼鼠和30日龄幼鼠海马体以及嗅皮质-杏仁核区域中脑鸟氨酸脱羧酶（ODC）的诱导情况。在幼鼠中，给予红藻氨酸4小时后，ODC水平适度升高（增加50%-80%），随后迅速恢复到对照水平。相反，在幼鼠中，给予红藻氨酸16小时后，ODC水平急剧升高17-25倍，并在注射后48-72小时降至基础水平。目前的结果表明，兴奋性毒性ODC诱导过程可分为两个阶段：第一阶段的特征是适度诱导，主要与脑回路的过度刺激有关；第二阶段中，酶的急剧刺激伴随着神经退行性病理变化的出现。
